Description

Boc-(R)-α-Benzyl-Proline is a high-purity, enantiomerically pure chiral building block essential for advanced organic synthesis. This compound matters for its critical role in constructing complex peptide and peptidomimetic structures, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D teams, process chemists, and fine chemical manufacturers engaged in developing novel therapeutics, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other peptide-based drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce a proline derivative with a protected amine (Boc) and a benzyl side chain for structural diversity.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in asymmetric catalytic reactions to construct stereogenic centers.
• Bioconjugation & Probe Development: Employed in the design and synthesis of labeled peptides and molecular probes for biochemical and diagnostic research.
• Chemical Biology Research: Utilized in the study of protein-protein interactions and enzyme mechanisms by incorporating modified proline residues.
• Process Development & Scale-up: A critical raw material for process chemistry during the optimization and commercial-scale manufacturing of chiral compounds.

Basic Information

Product Name	Boc-(R)-α-Benzyl-Proline
CAS No.	706806-60-2
Molecular Formula	C₁₈H₂₅NO₄
Molecular Weight	319.40 g/mol
Synonyms	(R)-1-[(tert-Butoxycarbonyl)]-2-benzylpyrrolidine-2-carboxylic Acid; (R)-1-Boc-2-benzylproline; (R)-1-(tert-Butoxycarbonyl)-2-benzylproline; (R)-2-Benzyl-1-[(tert-butoxycarbonyl)]proline; (R)-N-Boc-2-benzylproline; tert-Butyl (R)-2-benzyl-2-carboxypyrrolidine-1-carboxylate; Boc-D-Bzl-Pro-OH; Boc-(R)-2-Benzylproline
EINECS	Contact for details

Quality Control

Our Boc-(R)-α-Benzyl-Proline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.