Description

Mandelonitrile, 2-Methoxy-6-Methyl- (5Ci) is a specialized aromatic nitrile derivative, serving as a key chiral intermediate in advanced organic synthesis. Its value lies in its unique molecular structure, which provides a versatile scaffold for constructing complex molecules with high stereochemical control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals. The CAS number for this product is 705288-18-2.

Application

This versatile nitrile intermediate is utilized across several high-value chemical synthesis domains:

• Pharmaceutical Intermediate: A critical building block for the synthesis of chiral drug candidates, including potential CNS-active compounds and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific stereochemistry for optimal activity.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and other specialty chemicals where the methoxy-methyl substituted mandelonitrile structure is required.
• Academic & Industrial R&D: Employed in methodological studies for asymmetric synthesis, cyanohydrin chemistry, and the development of new catalytic processes.
• Ligand and Catalyst Development: The nitrile and aromatic ether functionalities make it a useful starting material for creating novel chiral ligands and organocatalysts.

Basic Information

Product Name	Mandelonitrile, 2-Methoxy-6-Methyl- (5Ci)
CAS No.	705288-18-2
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	2-Methoxy-6-methylmandelonitrile; (RS)-2-Methoxy-6-methylmandelonitrile; α-Hydroxy-2-methoxy-6-methylbenzeneacetonitrile; Benzeneacetonitrile, α-hydroxy-2-methoxy-6-methyl-; 2-(2-Methoxy-6-methylphenyl)-2-hydroxyacetonitrile; 5Ci-labeled Mandelonitrile derivative; Aryl cyanohydrin intermediate
EINECS	Contact for details

Quality Control

Our Mandelonitrile, 2-Methoxy-6-Methyl- (5Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specification parameters are provided and available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.