Description

Methyl 2-Bromo-5-Cyclopropylbenzoate is a high-purity, synthetically valuable benzoate ester derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic combination of a bromo substituent and a cyclopropyl group on the aromatic ring, enabling precise molecular construction and functionalization. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, where the cyclopropyl moiety can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals with tailored properties.
• Cross-Coupling Reactions: The bromoaryl group makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Heck couplings for carbon-carbon bond formation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	Methyl 2-Bromo-5-Cyclopropylbenzoate
CAS No.	702640-96-8
Molecular Formula	C11H11BrO2
Molecular Weight	255.11 g/mol
Synonyms	2-Bromo-5-cyclopropylbenzoic acid methyl ester; Methyl 2-bromo-5-cyclopropylbenzoate; Benzoic acid, 2-bromo-5-cyclopropyl-, methyl ester; 5-Cyclopropyl-2-bromobenzoic acid methyl ester; Methyl 5-cyclopropyl-2-bromobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-5-Cyclopropylbenzoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.