Description

Cyclobutanecarboxaldehyde, 2-[(Acetyloxy)Methyl]-, (1S,2S)- (9Ci) is a high-purity, chiral cyclobutane derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel pharmaceutical agents and fine chemicals. It is primarily utilized by research and development chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce complex, stereodefined cyclobutane motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of new active pharmaceutical ingredients (APIs), particularly for candidates containing strained ring systems.
• Asymmetric Synthesis: Employed as a precursor or reagent in stereoselective reactions to construct molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) guidelines.
• Agrochemical Synthesis: Potential intermediate for creating novel herbicides or insecticides with unique modes of action.
• Ligand and Catalyst Development: Can be utilized to synthesize novel chiral ligands for asymmetric catalysis.

Basic Information

Product Name	Cyclobutanecarboxaldehyde, 2-[(Acetyloxy)Methyl]-, (1S,2S)- (9Ci)
CAS No.	701292-26-4
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	(1S,2S)-2-(Acetoxymethyl)cyclobutanecarboxaldehyde; (1S,2S)-2-(Acetoxymethyl)cyclobutanecarbaldehyde; [(1S,2S)-2-Formylcyclobutyl]methyl acetate; (1S,2S)-rel-2-[(Acetyloxy)methyl]cyclobutanecarboxaldehyde; Cyclobutanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1S-cis)-; (1S,2S)-2-(Acetoxymethyl)-1-cyclobutanecarboxaldehyde
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxaldehyde, 2-[(Acetyloxy)Methyl]-, (1S,2S)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and GC-MS to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.