Description

2-[(1R,4R)-4-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclohexyl]Acetate is a high-purity, stereochemically defined boronic ester derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in enabling the precise construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) where stereochemistry is paramount. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for cross-coupling reactions and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel therapeutic agents, especially for targeted therapies and small-molecule drugs.
• Suzuki-Miyaura Cross-Coupling: Acts as a stable, air-tolerant boronic ester reagent for forming carbon-carbon bonds in complex molecule assembly.
• Agrochemical Research: Used in the development of new, stereoselective pesticides and herbicides with improved efficacy and environmental profiles.
• Liquid Crystal & OLED Materials: Serves as a building block for creating chiral dopants and advanced organic electronic materials with specific optical properties.
• Medicinal Chemistry & SAR Studies: Enables the exploration of structure-activity relationships by introducing the chiral cyclohexyl acetate moiety into candidate molecules.
• Asymmetric Synthesis: Utilized in catalytic asymmetric transformations to produce enantiomerically enriched compounds for high-value applications.

Basic Information

Item	Details
Product Name	2-[(1R,4R)-4-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclohexyl]Acetate
CAS No.	701232-69-1
Molecular Formula	C20H29BO4
Molecular Weight	344.26 g/mol
Synonyms	(1R,4R)-4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclohexyl acetate; (1R,4R)-2-(4-(4-Acetoxycyclohexyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; trans-4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclohexyl acetate; Chiral Boronic Ester Acetate; BoroPharm™ Intermediate 701232-69-1 (example trade name).
EINECS	Contact for details

Quality Control

Every batch of 2-[(1R,4R)-4-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclohexyl]Acetate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity, batch-to-batch consistency, and compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.