Description

3,4-Difluorophenylglyoxal Hydrate is a high-purity fluorinated aromatic glyoxal derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which can dramatically influence the electronic properties, metabolic stability, and binding affinity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct complex heterocycles and active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and kinase inhibitors.
• Agrochemical Synthesis: Building block for developing advanced herbicides and fungicides with enhanced efficacy and environmental profile.
• Material Science Research: Used in the development of organic electronic materials and fluorinated polymers.
• Chemical Biology Probes: Serves as a starting material for creating fluorescent tags and activity-based probes for enzyme studies.
• Cross-Coupling Reactions: Functional handle for palladium-catalyzed reactions to create complex biaryl structures.
• Heterocycle Construction: Core reagent for synthesizing imidazoles, oxazoles, and other nitrogen-containing heterocycles of commercial interest.

Basic Information

Item	Details
Product Name	3,4-Difluorophenylglyoxal Hydrate
CAS No.	79784-34-2
Molecular Formula	C8H6F2O3 • xH2O
Molecular Weight	188.13 (Anhydrous basis)
Synonyms	3,4-Difluorobenzoylformaldehyde Hydrate; (3,4-Difluorophenyl)-oxoacetaldehyde Hydrate; 2-Oxo-2-(3,4-difluorophenyl)acetaldehyde Hydrate; 3,4-Difluorophenylglyoxal Monohydrate; Glyoxal, (3,4-difluorophenyl)-, hydrate; 3,4-DFPG Hydrate
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylglyoxal Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent oxidation and moisture uptake. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.