Description

3-(Trifluoromethyl)-3-[M(Formamide)Phenyl]Diazirine is a specialized diazirine-based photoaffinity labeling reagent. This compound is valued for its ability to generate highly reactive carbene intermediates upon photolysis, enabling the covalent cross-linking and study of biomolecular interactions. It is primarily needed by researchers and manufacturers in pharmaceutical development, chemical biology, and proteomics for probing protein-ligand binding sites and mapping biological interfaces.

Application

• Photoaffinity Labeling (PAL): A critical tool for identifying and characterizing transient or weak interactions between small molecule drugs and their protein targets.
• Chemical Proteomics: Used in activity-based protein profiling (ABPP) to discover novel drug targets and understand mechanisms of action.
• Bioconjugation: Facilitates the site-specific covalent attachment of probes, tags, or drugs to biomolecules for diagnostic and therapeutic applications.
• Materials Science Research: Employed in surface modification and polymer cross-linking studies to create novel functional materials.
• Radioligand Development: Serves as a precursor for synthesizing tritiated or other radiolabeled analogs for sensitive binding assays.

Basic Information

Product Name	3-(Trifluoromethyl)-3-[M(Formamide)Phenyl]Diazirine
CAS No.	79684-40-5
Molecular Formula	C10H7F3N3O
Molecular Weight	242.18 g/mol
Synonyms	3-[3-(Trifluoromethyl)diazirin-3-yl]-N-formylaniline; 3-(Trifluoromethyl)-3-[3-(formylamino)phenyl]diazirine; 3-Formamidophenyl(trifluoromethyl)diazirine; TFD Formamide; Photoaffinity Labeling Reagent TFD-F; 3-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenylformamide; m-(Trifluoromethyl)diazirinylformanilide
EINECS	Contact for details

Quality Control

Our production of 3-(Trifluoromethyl)-3-[M(Formamide)Phenyl]Diazirine adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, consider storage under inert atmosphere at -20°C. Keep away from strong light sources and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (DMSO, DMF, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.