Description

Ethyl 6,7,8-Trifluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is a high-purity fluorinated quinoline derivative serving as a critical advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of antibacterial and anti-infective agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in the development of next-generation quinolone-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluoroquinolone antibiotics and other bioactive molecules.
• Antibacterial Drug Research: Used in medicinal chemistry for the research and development of new antibacterial agents targeting DNA gyrase and topoisomerase IV.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization to create libraries of quinoline derivatives for biological screening.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of candidate drugs.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis, heterocyclic chemistry, and pharmacology.

Basic Information

Product Name	Ethyl 6,7,8-Trifluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate
CAS No.	79660-46-1
Molecular Formula	C₁₂H₈F₃NO₃
Molecular Weight	271.19 g/mol
Synonyms	6,7,8-Trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate; 3-Quinolinecarboxylic acid, 1,4-dihydro-6,7,8-trifluoro-4-oxo-, ethyl ester; 6,7,8-Trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid Ethyl Ester; 79660-46-1; Ethyl 6,7,8-trifluoro-4-oxoquinoline-3-carboxylate (common abbreviation)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is analyzed to confirm identity, purity, and impurity profile. Certificates of Analysis (COA) documenting key parameters are available upon request. We adhere to strict internal quality management protocols to ensure batch-to-batch consistency and supply reliability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.