Description

Ethyl 4,4,4-Trifluoro-2-Butynoate is a high-value fluorinated building block and synthon, essential for introducing the trifluoromethylacetylene moiety into complex molecular architectures. Its unique structure combines an electron-withdrawing trifluoromethyl group with a reactive alkyne ester, making it a versatile intermediate for synthesizing advanced materials and bioactive compounds. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel fluorinated derivatives.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry for probing structure-activity relationships.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced materials with tailored surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel fluorinated ligands for catalysis and asymmetric synthesis.
• Fluorine Chemistry Research: A critical reagent in academic and industrial R&D for exploring new reactions and methodologies in fluoroorganic chemistry.
• Liquid Crystal and Electronic Material Synthesis: Used to incorporate fluorinated segments into molecules for electronic applications, including OLEDs and liquid crystal displays.

Basic Information

Product Name	Ethyl 4,4,4-Trifluoro-2-Butynoate
CAS No.	79424-03-6
Molecular Formula	C6H5F3O2
Molecular Weight	166.10 g/mol
Synonyms	Ethyl 4,4,4-Trifluorobut-2-ynoate; 4,4,4-Trifluoro-2-butynoic Acid Ethyl Ester; Ethyl Trifluoromethylpropiolate; 2-Butynoic Acid, 4,4,4-Trifluoro-, Ethyl Ester; Ethyl 3-Trifluoromethylpropiolate; TFBE; ETTB
EINECS	Contact for details

Quality Control

Our Ethyl 4,4,4-Trifluoro-2-Butynoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.