Description

Dimethyl 2,3-Difluorofumarate is a high-purity fluorinated building block essential for advanced organic synthesis. This compound is valued for its role as a versatile Michael acceptor and dienophile, enabling the efficient introduction of fluorine atoms and difluoromethylene units into complex molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging fluorine's ability to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorination improves efficacy and environmental persistence.
• Material Science: Serves as a monomer or precursor for developing fluorinated polymers, coatings, and liquid crystals with unique thermal, chemical, and surface properties.
• Organic Synthesis Reagent: Acts as a versatile electrophile in Diels-Alder reactions and Michael additions for constructing complex, fluorinated heterocycles and alicyclic compounds.
• Fluorine Chemistry Research: An important reagent for academic and industrial R&D focused on exploring new fluorination methodologies and fluorine-containing molecules.

Basic Information

Product Name	Dimethyl 2,3-Difluorofumarate
CAS No.	79322-43-3
Molecular Formula	C6H6F2O4
Molecular Weight	180.11 g/mol
Synonyms	2,3-Difluorofumaric Acid Dimethyl Ester; Dimethyl (E)-2,3-Difluorobut-2-enedioate; (E)-Dimethyl 2,3-Difluorofumarate; trans-Dimethyl 2,3-Difluorofumarate; 2,3-Difluoromaleic Acid Dimethyl Ester (isomer); DFMF; Methyl 2,3-difluorofumarate
EINECS	Contact for details

Quality Control

Our Dimethyl 2,3-Difluorofumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and consistent isomeric composition. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isomeric Purity (GC/HPLC)	≥ 99.0% (E-isomer)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.