Description

(4R,5α,8α,9S,10β,12S)-6α,18-Diacetoxy-4,19-Epoxy-12,16-Dihydroxy-1β-(Tigloyloxy)Cleroda-13-Ene-15-Oic Acid 15,16-Lactone is a highly functionalized clerodane diterpenoid lactone, a class of natural products known for their complex stereochemistry and significant biological activity. This compound is valued as a critical advanced pharmaceutical intermediate and a versatile scaffold for medicinal chemistry research. It is primarily sought by researchers and developers in the pharmaceutical, agrochemical, and fine chemical sectors for the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of potential therapeutic agents targeting inflammation, cancer, and infectious diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new drug candidates with optimized potency and selectivity.
• Natural Product Synthesis: Acts as a sophisticated intermediate in the total or semi-synthesis of complex clerodane diterpenoids and their analogs.
• Biochemical Probe Development: Utilized in the creation of molecular probes to study specific biological pathways and enzyme interactions.
• Agrochemical Research: Investigated as a lead compound for developing new-generation pesticides or plant growth regulators due to its natural origin and bioactivity.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Details
Product Name	(4R,5α,8α,9S,10β,12S)-6α,18-Diacetoxy-4,19-Epoxy-12,16-Dihydroxy-1β-(Tigloyloxy)Cleroda-13-Ene-15-Oic Acid 15,16-Lactone
CAS No.	78798-40-0
Molecular Formula	C32H40O12
Molecular Weight	616.66 g/mol
Synonyms	15,16-Lactone of (4R,5α,8α,9S,10β,12S)-6α,18-Diacetoxy-4,19-epoxy-12,16-dihydroxy-1β-(tigloyloxy)cleroda-13-en-15-oic acid; Clerodane diterpene lactone; 4,19-Epoxycleroda-13-ene-15,16-olide derivative; 1β-Tigloyloxy-6α,18-diacetoxy-4,19-epoxy-12,16-dihydroxycleroda-13-en-15,16-olide; 78798-40-0; A clerodane-type diterpenoid.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly. For long-term storage, consider storage under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.