Description

(4-Chlorophenylethynyl)Trimethylsilane CAS NO 78704-49-1 is a high-value organosilicon building block featuring a terminal alkyne protected by a trimethylsilyl (TMS) group and a para-chlorophenyl substituent. This compound is critical for advanced organic synthesis, particularly in cross-coupling reactions like Sonogashira couplings, where it serves as a versatile and stable intermediate. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring arylacetylene motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides that incorporate chlorinated aromatic systems.
• Material Science & Organic Electronics: Serves as a precursor for conjugated polymers, molecular wires, and organic light-emitting diodes (OLEDs) due to its rigid, linear alkyne structure.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organometallic complexes.
• Chemical Research & Development: A versatile reagent for academic and industrial research in synthetic methodology development and heterocyclic chemistry.
• Fine Chemical Production: Used in the multi-step synthesis of complex fragrance, flavor, and specialty chemical compounds.

Basic Information

Product Name	(4-Chlorophenylethynyl)Trimethylsilane
CAS No.	78704-49-1
Molecular Formula	C11H13ClSi
Molecular Weight	208.76 g/mol
Synonyms	1-Chloro-4-[(trimethylsilyl)ethynyl]benzene; 4-(Trimethylsilylethynyl)chlorobenzene; p-Chlorophenyl(trimethylsilyl)acetylene; TMS-Protected 4-Chlorophenylacetylene; Trimethyl((4-chlorophenyl)ethynyl)silane; 4-Chlorophenylethynyltrimethylsilane; (p-Chlorophenylethynyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our (4-Chlorophenylethynyl)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to prevent degradation upon repeated opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.