Description

1-[4-(Difluoromethoxy)Phenyl]-2-Methylpropan-1-One is a specialized aromatic ketone building block featuring a difluoromethoxy substituent. This compound is valued for its role as a key intermediate in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily sought by R&D chemists and process development teams in the fine chemical and life science industries for constructing complex molecules where the difluoromethoxy group can impart desirable metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic materials.
• Liquid Crystal & OLED Materials: A potential intermediate for creating fluorinated components used in electronic display technologies.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new fluorination chemistry pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.

Basic Information

Item	Details
Product Name	1-[4-(Difluoromethoxy)Phenyl]-2-Methylpropan-1-One
CAS No.	78682-09-4
Molecular Formula	C11H12F2O2
Molecular Weight	214.21 g/mol
Synonyms	4'-(Difluoromethoxy)isobutyrophenone; p-(Difluoromethoxy)isobutyrophenone; 1-[4-(Difluoromethoxy)phenyl]-2-methyl-1-propanone; 2-Methyl-1-[4-(difluoromethoxy)phenyl]propan-1-one; Isobutyryl-4-difluoromethoxybenzene; α,α-Dimethyl-4-(difluoromethoxy)acetophenone
EINECS	Contact for details

Quality Control

Our production of 1-[4-(Difluoromethoxy)Phenyl]-2-Methylpropan-1-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets exacting customer specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We operate under a quality system designed to support cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.