Description

4-(T-Butyldimethylsiloxy)Butyne is a specialized organosilicon building block featuring a terminal alkyne group protected by a tert-butyldimethylsilyl (TBDMS) ether. This compound is valued for its role as a key synthetic intermediate in advanced organic synthesis, particularly in the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as click chemistry, cross-coupling reactions, and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring alkyne functionalization.
• Click Chemistry Reagent: Used in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer modification, and material surface functionalization.
• Agrochemical Synthesis: Serves as an intermediate in the production of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Employed in the synthesis of advanced polymers, dendrimers, and functionalized surfaces with tailored properties.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Protecting Group Strategy: The TBDMS-protected alkyne allows for selective deprotection and further functionalization in multi-step synthetic sequences.

Basic Information

Product Name	4-(T-Butyldimethylsiloxy)Butyne
CAS No.	78592-82-2
Molecular Formula	C10H20OSi
Molecular Weight	184.35 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]-1-butyne; 4-(tert-Butyldimethylsiloxy)-1-butyne; 1-Butyne, 4-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 4-(TBDMSO)-1-butyne; 4-(tert-Butyldimethylsilyloxy)but-1-yne; TBDMS-protected 3-butyn-1-ol; 3-Butyn-1-ol, 1-(1,1-dimethylethyl)dimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 4-(T-Butyldimethylsiloxy)Butyne is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and process-scale applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.