Description

Pentafluoroethanesulfonamide is a high-value fluorinated sulfonamide derivative, recognized for its unique chemical structure that imparts significant electron-withdrawing properties and stability. This compound is crucial as a versatile building block and intermediate in advanced synthetic chemistry, enabling the development of novel materials and active ingredients. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise fluorination and robust sulfonamide functionality.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in sulfonamide-based drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the pentafluoroethyl group enhances biological activity and environmental persistence.
• Polymer & Material Science: Serves as a monomer or modifier in the synthesis of specialty polymers, including ion-exchange resins and high-performance fluoropolymers.
• Ligand & Catalyst Design: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging its strong electron-withdrawing character.
• Electrolyte Additive: Investigated for use in lithium-ion battery electrolytes to improve stability and performance at high voltages.
• Organic Synthesis Building Block: A versatile reagent for introducing the pentafluoroethanesulfonyl (PES) group into complex molecules via nucleophilic substitution or coupling reactions.

Basic Information

Product Name	Pentafluoroethanesulfonamide
CAS No.	78491-70-0
Molecular Formula	C₂H₂F₅NO₂S
Molecular Weight	199.10 g/mol
Synonyms	1,1,2,2,2-Pentafluoroethanesulfonamide; Pentafluoroethylsulfonamide; Pentafluoroethanesulfonic acid amide; PES-NH₂; Perfluoroethanesulfonamide; NSC 405124; 2,2,2-Trifluoro-1-(trifluoromethyl)ethanesulfonamide
EINECS	Contact for details

Quality Control

Our Pentafluoroethanesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.