Description

(Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl)Methanol is a specialized pyrrolizidine-based organic building block of significant interest in advanced chemical synthesis. This compound serves as a crucial chiral intermediate for constructing complex molecular architectures with high stereochemical fidelity. It is primarily sought after by research institutions and pharmaceutical development companies engaged in the creation of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of potential therapeutic agents, particularly for alkaloid-derived pharmaceuticals.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the pyrrolizidine scaffold into target molecules.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Fine Chemical Production: Used in the multi-step synthesis of complex, high-value specialty chemicals and advanced materials.
• Academic & Contract Research: Serves as a reference standard and starting material in academic laboratories and CROs (Contract Research Organizations) for methodological development.

Basic Information

Product Name	(Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl)Methanol
CAS No.	78449-72-6
Molecular Formula	C8H15NO
Molecular Weight	141.21 g/mol
Synonyms	7a(Hydroxymethyl)hexahydro-1H-pyrrolizine; 7a-(Hydroxymethyl)hexahydro-1H-pyrrolizine; 1H-Pyrrolizine-7a(5H)-methanol, tetrahydro-; Tetrahydro-1H-pyrrolizine-7a(5H)-methanol; (7aR)-Hexahydro-1H-pyrrolizine-7a-methanol; (7aS)-Hexahydro-1H-pyrrolizine-7a-methanol; Pyrrolizidine-7a-methanol
EINECS	Contact for details

Quality Control

Our (Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl)Methanol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including chiral purity assessment via HPLC. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (enantiomer-specific grades available)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.