Description

4-Fluorobicyclo[2.2.2]octane-1-carboxylic acid is a highly functionalized, rigid bicyclic carboxylic acid derivative, distinguished by the strategic incorporation of a fluorine atom. This compound is a valuable advanced pharmaceutical intermediate (API) and a versatile building block in medicinal chemistry and materials science. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and metabolic disease research.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid, three-dimensional scaffold and fluorine atom, which can modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides and pesticides, where the fluorine atom enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: The carboxylic acid functionality allows for chelation to metals, making it useful in designing new catalysts and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to introduce fluorinated, rigid units into polymer backbones to alter thermal stability, chemical resistance, and surface properties.
• Chemical Biology Probes: Utilized in the synthesis of probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	4-Fluorobicyclo[2.2.2]octane-1-carboxylic Acid
CAS No.	78385-84-9
Molecular Formula	C9H11FO2
Molecular Weight	170.18 g/mol
Synonyms	4-Fluorobicyclo[2.2.2]octane-1-carboxylic acid; 1-Carboxy-4-fluorobicyclo[2.2.2]octane; 4-Fluoro-1-bicyclo[2.2.2]octanecarboxylic acid; Bicyclo[2.2.2]octane-1-carboxylic acid, 4-fluoro-; 4-Fluoroadamantane-1-carboxylic acid (structural analog name); 4-Fluoro-BCO-1-COOH; F-BCO-COOH
EINECS	Contact for details

Quality Control

Our 4-Fluorobicyclo[2.2.2]octane-1-carboxylic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.