Description

Fluoromethylglyoxal is a versatile and highly reactive fluorinated building block, essential for advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a glyoxal moiety, makes it a critical intermediate for introducing fluoromethyl ketone functionalities into target molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop novel active ingredients with enhanced metabolic stability and bioavailability. Fluoromethylglyoxal CAS NO 78381-94-9 enables precise molecular modifications that are key to modern drug discovery and crop protection science.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluoromethyl group improves compound efficacy and environmental profile.
• Fluorine Chemistry Research: Serves as a fundamental building block in academic and industrial R&D for exploring new fluorination methodologies and creating fluorinated compound libraries.
• Material Science Precursor: Employed in the synthesis of specialized fluorinated polymers and advanced materials with unique surface properties.
• Bioconjugation & Probe Development: Useful for labeling biomolecules or creating chemical probes for biochemical and diagnostic applications.

Basic Information

Product Name	Fluoromethylglyoxal
CAS No.	78381-94-9
Molecular Formula	C3H3FO2
Molecular Weight	90.05 g/mol
Synonyms	2-Fluoromethyl-1,2-ethanedione; 2-Fluoro-2-oxoacetaldehyde; 2-Fluoromethylglyoxal; 2-Fluoro-2-oxoethanal; Glyoxal, 2-fluoromethyl-; 1-Fluoro-1,2-dioxobutane; 2-Fluoromethyl-2-oxoacetaldehyde; FMG
EINECS	Contact for details

Quality Control

Every batch of Fluoromethylglyoxal is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports your compliance needs for research, development, and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and other fluorides. Due to its reactive nature, it is recommended to use the product promptly after opening the primary container.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.