Description

(+/-)-trans-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid CAS NO 78376-99-5 is a high-value, chiral cyclopropane derivative featuring a trifluoromethyl group, a structural motif of significant interest in modern synthetic chemistry. This compound serves as a versatile and critical advanced pharmaceutical intermediate (API) and a key building block for the synthesis of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, antiviral agents, and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the cyclopropane and trifluoromethyl groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry in complex reactions.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials where the introduction of fluorine atoms can alter physical properties like solubility, thermal stability, and surface energy.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and bio-conjugation reagents due to its unique three-dimensional structure and potential for further functionalization.
• Process Chemistry & Scale-up: Provides a defined chiral starting point for the optimization and large-scale production of enantiomerically enriched target molecules.

Basic Information

Product Name	(+/-)-trans-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid
CAS No.	78376-99-5
Molecular Formula	C5H5F3O2
Molecular Weight	154.09 g/mol
Synonyms	trans-2-(Trifluoromethyl)cyclopropanecarboxylic acid (racemic); (±)-trans-2-(Trifluoromethyl)cyclopropanecarboxylic acid; rac-trans-2-(Trifluoromethyl)cyclopropanecarboxylic acid; 2-(Trifluoromethyl)cyclopropanecarboxylic acid (trans-); Cyclopropanecarboxylic acid, 2-(trifluoromethyl)-, trans-; 1,2-cis-2-(Trifluoromethyl)cyclopropanecarboxylic acid (common misnomer); TFCA (abbreviation); 78376-99-5
EINECS	Contact for details

Quality Control

Our (+/-)-trans-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral analysis, to ensure identity, purity, and enantiomeric composition meet exacting customer specifications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality systems support development from milligram to kilogram scale with consistent traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its acidic nature, keep away from strong bases, oxidizing agents, and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Ratio (Chiral HPLC)	~50:50 (racemic)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.