Description

(+/-)-(2-trans-(Trifluoromethyl)Cyclopropyl)Methanol is a versatile fluorinated cyclopropane derivative, a high-value chiral building block prized for its unique structural motif. Its core value lies in enabling the synthesis of complex molecules with enhanced metabolic stability and lipophilicity, critical for advanced material and pharmaceutical development. This compound is essential for R&D chemists and process engineers in the agrochemical, pharmaceutical, and specialty chemical industries seeking to incorporate the trifluoromethylcyclopropyl pharmacophore.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Asymmetric Catalysis & Ligand Design: Employed as a scaffold for constructing chiral ligands and catalysts in enantioselective synthesis.
• Fluorinated Polymer Modification: Acts as a monomer or modifier to introduce cyclopropyl and fluorine functionalities into specialty polymers, enhancing chemical resistance and material properties.
• Chemical Research & Development: A valuable tool for exploratory organic synthesis and methodology development in academic and industrial laboratories.

Basic Information

Product Name	(+/-)-(2-trans-(Trifluoromethyl)Cyclopropyl)Methanol
CAS No.	78376-92-8
Molecular Formula	C5H7F3O
Molecular Weight	140.11 g/mol
Synonyms	(±)-trans-2-(Trifluoromethyl)cyclopropanemethanol; (trans-2-(Trifluoromethyl)cyclopropyl)methanol; 2-(Trifluoromethyl)cyclopropanemethanol (trans-); (2-trans-(Trifluoromethyl)Cyclopropyl)Methanol; rac-(1R,2S)-2-(Trifluoromethyl)cyclopropanemethanol; (1RS,2SR)-2-(Trifluoromethyl)cyclopropylmethanol
EINECS	Contact for details

Quality Control

Our (+/-)-(2-trans-(Trifluoromethyl)Cyclopropyl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profile analysis, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by GC/HPLC), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its properties as a fluoride/strong alkali and highly volatile compound, ensure containers are kept tightly sealed and away from incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Trans/Cis Isomer Ratio (GC)	≥95:5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.