Description

3-Chloro-4-(Trifluoromethoxy)Phenylacetonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its unique halogenated and trifluoromethoxy substituents. This compound is critical for synthesizing advanced pharmaceutical intermediates and agrochemical active ingredients, where its structural motifs confer desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a core building block for developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy and chloro groups.
• Ligand and Catalyst Development: Used in organic and organometallic chemistry to create novel ligands for catalysis and molecular recognition applications.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and organic electronic materials due to its aromatic and electron-withdrawing properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethoxy)Phenylacetonitrile
CAS No.	78240-45-6
Molecular Formula	C9H5ClF3NO
Molecular Weight	235.59 g/mol
Synonyms	2-(3-Chloro-4-(trifluoromethoxy)phenyl)acetonitrile; (3-Chloro-4-(trifluoromethoxy)phenyl)acetonitrile; 3-Chloro-4-trifluoromethoxyphenylacetonitrile; 2-(3-Chloro-4-(trifluoromethoxy)phenyl)ethanenitrile; α-Cyano-3-chloro-4-trifluoromethoxy toluene; 78240-45-6; 3-Chloro-4-(trifluoromethoxy)benzyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Trifluoromethoxy)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.