Description

2-Trifluoromethylimidazole-4-Carboxylic Acid is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of pharmaceuticals and agrochemicals, where the trifluoromethyl group imparts desirable metabolic stability and lipophilicity. It is primarily needed by research and development chemists in the pharmaceutical industry, as well as by manufacturers of specialty fine chemicals and active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced materials with unique properties.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for metal catalysis and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up services for clients in the life sciences sector.

Basic Information

Product Name	2-Trifluoromethylimidazole-4-Carboxylic Acid
CAS No.	78016-98-5
Molecular Formula	C5H3F3N2O2
Molecular Weight	180.09 g/mol
Synonyms	2-(Trifluoromethyl)-1H-imidazole-4-carboxylic acid; 2-(Trifluoromethyl)-4-imidazolecarboxylic Acid; 4-Carboxy-2-trifluoromethylimidazole; 1H-Imidazole-4-carboxylic acid, 2-(trifluoromethyl)-; 2-Trifluoromethyl-1H-imidazole-4-carboxylic acid; 2-Trifluoromethyl-4-imidazolecarboxylic Acid; TFMI-4-COOH
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethylimidazole-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.