Description

(R)-1,4-Dioxaspiro[4.5]decane-2-carboxaldehyde is a high-value chiral building block and aldehyde derivative of spirocyclic ketal. This compound matters for its role as a versatile intermediate in the synthesis of complex, stereochemically defined molecules, particularly in pharmaceutical research and development. It is primarily needed by fine chemical manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and specialty chemical industries for constructing chiral centers in target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a specific (R)-configuration.
• Asymmetric Synthesis: Used in stereoselective reactions, such as nucleophilic additions or reductive aminations, to introduce chirality into complex organic frameworks.
• Agrochemical Research: Serves as a building block for developing novel chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Preparation: Utilized in the preparation of chiral ligands for transition metal catalysis or organocatalysts.
• Fragrance and Flavor Chemistry: Potential intermediate for the synthesis of stereochemically pure odorants and flavor compounds.
• Academic and R&D: Employed in methodological studies and the discovery of new synthetic routes in organic chemistry laboratories worldwide.

Basic Information

Product Name	(R)-1,4-Dioxaspiro[4.5]decane-2-carboxaldehyde
CAS No.	78008-36-3
Molecular Formula	C9H14O3
Molecular Weight	170.21 g/mol
Synonyms	(R)-1,4-Dioxaspiro[4.5]decane-2-carbaldehyde; (R)-2-Formyl-1,4-dioxaspiro[4.5]decane; (R)-Spiro[1,3-dioxolane-2,1'-cyclohexane]-4-carboxaldehyde; (R)-Cyclohexanone ethylene ketal-2-carboxaldehyde; (R)-2-(1,4-Dioxaspiro[4.5]dec-2-yl)carbaldehyde; (R)-1,4-Dioxaspiro[4.5]decan-2-carboxaldehyde; (2R)-1,4-Dioxaspiro[4.5]decane-2-carbaldehyde
EINECS	Contact for details

Quality Control

Our (R)-1,4-Dioxaspiro[4.5]decane-2-carboxaldehyde is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing specific parameters such as enantiomeric excess (ee), chemical purity, and identity confirmation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.