Description

5-(Trifluoromethyl)Oxolane-2-Carboxylic Acid is a high-value fluorinated heterocyclic building block, distinguished by its unique combination of a tetrahydrofuran ring and a trifluoromethyl group. This structure is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules in advanced synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, antiviral, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, leveraging the stereogenic center of the oxolane ring.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals to impart unique surface properties and chemical resistance.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	5-(Trifluoromethyl)Oxolane-2-Carboxylic Acid
CAS No.	77899-95-7
Molecular Formula	C6H7F3O3
Molecular Weight	184.11 g/mol
Synonyms	2-(Trifluoromethyl)tetrahydrofuran-2-carboxylic acid; 5-(Trifluoromethyl)tetrahydro-2-furancarboxylic acid; α-(Trifluoromethyl)tetrahydro-2-furancarboxylic acid; 2-Tetrahydrofurancarboxylic acid, 2-(trifluoromethyl)-; 5-(Trifluoromethyl)dihydro-2(3H)-furanone-3-carboxylic acid (tautomer); TFMOA; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Oxolane-2-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.