Description

2,4,6-Trinitrophenyl 5-Oxo-L-Prolinate is a specialized chemical derivative of L-proline, featuring a trinitrophenyl (picryl) ester group. This compound is valued for its role as a key synthetic intermediate and a potential analytical reagent in advanced organic synthesis and biochemical research. It is primarily utilized by research institutions and pharmaceutical development companies working on peptide mimetics, enzyme inhibitors, and other complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel peptide-based drugs and prodrugs.
• Biochemical Research: Used in the study of enzyme kinetics and inhibition, particularly for proline-specific enzymes.
• Proteomics & Labeling: Acts as a potential derivatization agent or active ester for modifying peptides and proteins in analytical workflows.
• Organic Synthesis: Employed as a protected or activated form of 5-oxoproline for constructing complex molecular architectures.
• Reference Standard: Supplied as a high-purity compound for analytical method development and quality control in regulated laboratories.

Basic Information

Product Name	2,4,6-Trinitrophenyl 5-Oxo-L-Prolinate
CAS No.	77795-25-6
Molecular Formula	C11H8N4O9
Molecular Weight	340.21 g/mol
Synonyms	5-Oxo-L-proline 2,4,6-trinitrophenyl ester; L-Pyroglutamic acid picryl ester; Picryl L-pyroglutamate; 2,4,6-Trinitrophenyl L-pyroglutamate; (S)-2,4,6-Trinitrophenyl 5-oxopyrrolidine-2-carboxylate; TNP-5-oxo-L-prolinate; TNP-L-pyroglutamate
EINECS	Contact for details

Quality Control

Our 2,4,6-Trinitrophenyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its properties as a strong oxidizing agent, store separately from combustible materials and reducing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.