Description

3-Hydroxy-4-Methyl-2-Pyrrolidinecarboxylic Acid is a specialized chiral pyrrolidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique stereochemistry and functional groups, enabling the construction of complex molecules with high precision. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those targeting neurological and metabolic disorders.
• Agrochemical Synthesis: Used in the research and development of novel, enantiomerically pure pesticides and herbicides.
• Catalyst & Ligand Precursor: Serves as a starting material for the preparation of chiral catalysts and ligands used in asymmetric synthesis.
• Biochemical Research: Employed in the study of enzyme inhibitors and as a probe molecule in metabolic pathway research.
• Fine Chemical Production: A versatile intermediate for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	3-Hydroxy-4-Methyl-2-Pyrrolidinecarboxylic Acid
CAS No.	77647-24-6
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	4-Methyl-3-hydroxy-2-pyrrolidinecarboxylic acid; (3R,4R)-3-Hydroxy-4-methylpyrrolidine-2-carboxylic acid; (3S,4S)-3-Hydroxy-4-methylpyrrolidine-2-carboxylic acid; 3-Hydroxy-4-methyl-DL-proline; 3-Hydroxy-4-methylproline; 4-Methyl-3-hydroxyproline; 2-Pyrrolidinecarboxylic acid, 3-hydroxy-4-methyl-
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-4-Methyl-2-Pyrrolidinecarboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer excess)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.