Description

2-[4-(5-Ethylthiophene-2-Carbonyl)Phenyl]Propanoic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of advanced pharmaceutical active ingredients, particularly COX-2 inhibitors. It is essential for manufacturers in the pharmaceutical and fine chemical sectors requiring reliable, high-quality raw materials for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of selective COX-2 inhibitor drugs, such as Etoricoxib and related analogues.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of non-steroidal anti-inflammatory drugs (NSAIDs) for pain and inflammation management.
• Fine Chemical Synthesis: Serves as a versatile building block for creating novel chemical entities in medicinal chemistry research and development.
• Biochemical Research: Utilized in laboratory studies to investigate cyclooxygenase enzyme pathways and inflammatory mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of final dosage forms.

Basic Information

Product Name	2-[4-(5-Ethylthiophene-2-Carbonyl)Phenyl]Propanoic Acid
CAS No.	77614-41-6
Molecular Formula	C₁₇H₁₆O₃S
Molecular Weight	300.37 g/mol
Synonyms	5-Ethyl-2-(4-(1-carboxyethyl)benzoyl)thiophene; 2-(4-(5-Ethyl-2-thienylcarbonyl)phenyl)propanoic Acid; Etoricoxib Intermediate; L-748780; COX-2 Inhibitor Intermediate; [4-(5-Ethylthiophene-2-Carbonyl)Phenyl]Propionic Acid; MK-0663 Intermediate
EINECS	Contact for details

Quality Control

Our 2-[4-(5-Ethylthiophene-2-Carbonyl)Phenyl]Propanoic Acid is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical intermediate applications, with comprehensive testing including identity, assay, and impurity profile analysis. A Certificate of Analysis (COA) is provided with each batch, and we can support compliance with relevant pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.