Description

(4R,5β,8α,9β,10α,12α)-9,15β-Dihydroxyatis-16-En-18-Oic Acid is a high-purity diterpenoid compound with a complex, defined stereochemistry, making it a valuable intermediate for advanced organic synthesis. Its significance lies in its unique atisane-type skeleton, which serves as a critical building block for the research and development of novel pharmaceutical agents and bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require structurally precise intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in oncology and metabolic disease research.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Development: Employed in route scouting and optimization for the scalable production of complex diterpenoid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Investigated for its potential biological activity and interaction with specific enzymes or receptors.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex natural product analogs and specialty chemicals.

Basic Information

Product Name	(4R,5β,8α,9β,10α,12α)-9,15β-Dihydroxyatis-16-En-18-Oic Acid
CAS No.	77533-69-8
Molecular Formula	C₂₀H₃₀O₅
Molecular Weight	350.45 g/mol
Synonyms	9,15β-Dihydroxyatis-16-en-18-oic Acid; Atis-16-ene-18-oic acid, 9,15-dihydroxy-, (4R,5β,8α,9β,10α,12α)-; ent-9,15α-Dihydroxyatis-16-en-18-oic Acid (enantiomer); Atisane Diterpenoid Acid; Dihydroxyatisene Carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of (4R,5β,8α,9β,10α,12α)-9,15β-Dihydroxyatis-16-En-18-Oic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.