Description

5-Chloro-2-Formylbenzonitrile is a versatile and high-purity aromatic aldehyde nitrile derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a formyl and a nitrile group on a chlorinated benzene ring, enables precise molecular construction for complex target molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for molecules with benzodiazepine or other fused heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the chloro and formyl groups allow for strategic derivatization.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers where specific electronic and steric properties are required.
• Custom Synthesis and Contract Manufacturing: A valuable substrate for fine chemical and custom synthesis houses producing bespoke compounds for client R&D programs.

Basic Information

Product Name	5-Chloro-2-Formylbenzonitrile
CAS No.	77532-88-8
Molecular Formula	C8H4ClNO
Molecular Weight	165.57 g/mol
Synonyms	2-Cyano-4-chlorobenzaldehyde; 4-Chloro-2-cyanobenzaldehyde; 5-Chloro-2-cyanobenzaldehyde; 2-Formyl-5-chlorobenzonitrile; 4-Chlorophthalaldehyde nitrile; Benzonitrile, 5-chloro-2-formyl-; 5-Chlorosalicylonitrile (misnomer, but sometimes used)
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Formylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) with full traceability are provided with each shipment. We support compliance with relevant frameworks such as cGMP, ISO, and REACH for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.