Description

2'-Fluoro-2-Phenylacetophenone is a high-value fluorinated aromatic ketone, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a phenylacetophenone backbone and a fluorine substituent, makes it indispensable for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluorinated drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental stability.
• Ligand and Catalyst Synthesis: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Employed in the research of organic electronic materials and liquid crystals, where fluorinated aromatic systems are valuable.
• Academic & R&D: A versatile reagent for methodological studies in organic chemistry, particularly in cross-coupling and fluorination reaction research.

Basic Information

Product Name	2'-Fluoro-2-Phenylacetophenone
CAS No.	77294-82-7
Molecular Formula	C14H11FO
Molecular Weight	214.24 g/mol
Synonyms	2'-Fluoro-2-phenylacetophenone; 2-Fluoro-2-phenylacetophenone; 1-(2-Fluorophenyl)-2-phenylethan-1-one; 2-Fluorodesoxybenzoin; α-Phenyl-2-fluoroacetophenone; (2-Fluorophenyl)(phenyl)methanone (common misnomer); 2-Fluoro-α-phenylacetophenone; 2'-Fluorochalcone precursor
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity for research and production use. Our standard grade for 2'-Fluoro-2-Phenylacetophenone typically meets a purity specification of ≥97% (by HPLC), with comprehensive identity confirmation via NMR and FT-IR. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom synthesis to meet specific purity or analytical criteria (e.g., ≥99% for advanced applications) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.