Description

4-Hydroxy-3-Methyl-Butanoic Acid is a valuable chiral building block and intermediate in organic synthesis. This compound matters for its role in the production of pharmaceuticals, fine chemicals, and flavor & fragrance ingredients, offering a versatile structure for further chemical modification. It is needed by research institutions, pharmaceutical manufacturers, and specialty chemical producers engaged in developing active pharmaceutical ingredients (APIs), nutraceuticals, and high-value aroma chemicals.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of various active pharmaceutical ingredients (APIs) and statin drugs.
• Flavor and Fragrance Industry: Used in the production of esters and lactones that contribute to fruity, creamy, or coconut-like aroma profiles.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex molecules in agrochemical and material science research.
• Nutraceutical Precursor: Potential intermediate in the synthesis of compounds like HMB (β-hydroxy β-methylbutyrate) and related metabolites.
• Biochemical Research: Used in studies of metabolic pathways and as a standard in analytical chemistry.
• Polymer Modification: Can be utilized to introduce hydroxyl functionality into polymers for specialty material applications.

Basic Information

Product Name	4-Hydroxy-3-Methyl-Butanoic Acid
CAS No.	77220-86-1
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	3-Methyl-4-hydroxybutanoic acid; 4-Hydroxy-3-methylbutyric acid; 3-Methyl-4-hydroxybutyric acid; β-Hydroxy-β-methylbutyric acid (HMB) precursor; 3-Methylbutane-1,4-dioic acid (tautomer); 4-Hydroxyisovaleric acid; (R/S)-4-Hydroxy-3-methylbutanoic acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-Methyl-Butanoic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay, chiral purity (if applicable), and impurity profiles are provided with every shipment. We can support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant pharmaceutical or food-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Chiral Purity (if applicable)	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.