Description

2-(Trimethylsilyl)Ethynylbenzaldehyde is a versatile organosilicon building block featuring both an aldehyde and a protected terminal alkyne functional group. This bifunctional nature makes it a critical intermediate for constructing complex molecular architectures via sequential coupling and cyclization reactions. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry and organic synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing fused heterocyclic systems and conjugated molecular scaffolds.
• Agrochemical Synthesis: Used in the development of novel fungicides, herbicides, and plant growth regulators that require specific aromatic and alkyne motifs.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, dendrimers, and organic electronic materials.
• Organic Synthesis Building Block: Enables Sonogashira coupling, click chemistry, and other palladium-catalyzed cross-coupling reactions to introduce ethynylbenzaldehyde units into target molecules.
• Ligand and Catalyst Development: Utilized for the preparation of novel chelating ligands and organometallic catalysts for asymmetric synthesis.
• Fluorescent Probe and Dye Synthesis: Acts as a starting material for creating advanced fluorescent markers and molecular sensors due to its conjugated system potential.

Basic Information

Product Name	2-(Trimethylsilyl)Ethynylbenzaldehyde
CAS No.	77123-58-1
Molecular Formula	C₁₂H₁₄OSi
Molecular Weight	202.33 g/mol
Synonyms	2-[(Trimethylsilyl)ethynyl]benzaldehyde; o-(Trimethylsilylethynyl)benzaldehyde; Benzaldehyde, 2-[(trimethylsilyl)ethynyl]-; 2-Ethynylbenzaldehyde trimethylsilyl ether; TMS-Ethynylbenzaldehyde
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Ethynylbenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.