Description

3-(Trimethylsilyl)Ethynylbenzaldehyde is a specialized organosilicon building block featuring both an aldehyde and a protected terminal alkyne functional group. This unique bifunctional structure makes it a versatile intermediate for advanced organic synthesis, particularly in constructing complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require high-purity, functionalized intermediates for drug discovery and advanced polymer development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in creating novel fungicides and herbicides with enhanced efficacy and environmental profiles.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in click chemistry applications (via the alkyne group) for bioconjugation and labeling of biomolecules.
• Organic Synthesis Research: A valuable reagent for academic and industrial R&D in constructing complex heterocycles and natural product analogs.

Basic Information

Product Name	3-(Trimethylsilyl)Ethynylbenzaldehyde
CAS No.	77123-55-8
Molecular Formula	C₁₂H₁₄OSi
Molecular Weight	202.33 g/mol
Synonyms	3-((Trimethylsilyl)ethynyl)benzaldehyde; m-((Trimethylsilyl)ethynyl)benzaldehyde; 3-Ethynylbenzaldehyde trimethylsilyl ether; Benzaldehyde, 3-[(trimethylsilyl)ethynyl]-; TMS-Ethynylbenzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-(Trimethylsilyl)Ethynylbenzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.