Description

(R)-(+)-2-(tert-Butoxycarbonylamino)-3-Phenylpropanal is a high-value chiral aldehyde building block, essential for the synthesis of enantiomerically pure compounds. Its primary value lies in its role as a key intermediate for introducing the (R)-2-amino-3-phenylpropyl moiety, a structural motif found in numerous bioactive molecules. This compound is critically needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of chiral drugs, particularly enzyme inhibitors and receptor antagonists.
• Peptidomimetic Synthesis: Used to construct non-natural amino acid derivatives and constrained peptide analogs for drug discovery.
• Asymmetric Catalysis: Serves as a chiral ligand precursor or auxiliary in stereoselective chemical transformations.
• API Development: Integral for building complex molecular architectures in the late-stage functionalization of candidate drugs.
• Biochemical Research: Employed in the study of enzyme-substrate interactions and the design of molecular probes.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	(R)-(+)-2-(tert-Butoxycarbonylamino)-3-Phenylpropanal
CAS No.	77119-85-8
Molecular Formula	C14H19NO3
Molecular Weight	249.31 g/mol
Synonyms	(R)-Boc-Phenylalaninal; (R)-N-Boc-3-Phenylalaninal; (R)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanal; (R)-N-(tert-Butoxycarbonyl)-3-phenylalaninal; Boc-D-Phenylalaninal; (R)-Boc-Phe-H; (2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanal
EINECS	Contact for details

Quality Control

Our (R)-(+)-2-(tert-Butoxycarbonylamino)-3-Phenylpropanal is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, critical for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity (typically ≥99% ee), and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality control protocols include stringent identity confirmation and stability testing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.