Description

1-Iodobut-2-yne is a versatile halogenated alkyne building block, essential for advanced organic synthesis and material science research. Its unique structure, featuring both an iodine atom and a terminal alkyne group, makes it a critical reagent for cross-coupling reactions and click chemistry applications. This high-purity intermediate is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators that require alkyne-functionalized cores.
• Material Science: Acts as a monomer or functionalization agent in the synthesis of conductive polymers, metal-organic frameworks (MOFs), and other advanced materials.
• Click Chemistry: An ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling the rapid and modular assembly of complex molecules.
• Ligand & Catalyst Development: Employed in the preparation of specialized phosphine or N-heterocyclic carbene (NHC) ligands for catalysis.
• Organic Synthesis Building Block: Facilitates carbon-carbon and carbon-heteroatom bond formation in multi-step synthetic routes for fine chemicals.

Basic Information

Item	Detail
Product Name	1-Iodobut-2-yne
CAS No.	76778-00-2
Molecular Formula	C4H5I
Molecular Weight	179.99 g/mol
Synonyms	But-2-yn-1-yl iodide; 2-Butyn-1-yl iodide; 1-Iodo-2-butyne; 3-Iodo-1-propyne; Iodobut-2-yne; 2-Butynyl iodide
EINECS	Contact for details

Quality Control

Our 1-Iodobut-2-yne is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from GC, HPLC, and NMR analyses. Our quality system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.