Description

2-(Trimethylsilyl)Ethoxymethyl Chloride is a versatile organosilicon protecting group reagent, primarily used for the protection of alcohols and amines in multi-step organic synthesis. Its core value lies in its stability under basic conditions and its selective deprotection under mild acidic conditions, enabling complex molecule construction. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable and high-purity building blocks for sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for protecting hydroxyl and amino groups during the synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Peptide Chemistry: Used for the temporary protection of serine, threonine, or tyrosine side chains in solid-phase and solution-phase peptide synthesis.
• Agrochemical Development: Employed in the multi-step synthesis of novel herbicides, fungicides, and plant growth regulators requiring selective protection strategies.
• Nucleoside & Nucleotide Chemistry: Facilitates the protection of sugar hydroxyl groups in the synthesis of modified nucleosides and oligonucleotide precursors.
• Material Science Research: Serves as a functionalization agent in the surface modification of silica or in the synthesis of specialized silicone-based polymers.
• Academic & Process Chemistry: A standard tool in research laboratories and process development for investigating new synthetic routes and scaling up reactions.

Basic Information

Product Name	2-(Trimethylsilyl)Ethoxymethyl Chloride
CAS No.	76513-69-4
Molecular Formula	C6H15ClOSi
Molecular Weight	166.72 g/mol
Synonyms	SEM-Cl; (2-(Chloromethoxy)ethoxy)trimethylsilane; 2-Trimethylsilylethoxymethyl chloride; Chloromethyl 2-trimethylsilylethyl ether; β-Trimethylsilylethoxymethyl chloride; 2-[(Chloromethoxy)ethyl]trimethylsilane; 1-[(2-Trimethylsilyl)ethoxy]methyl chloride
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Ethoxymethyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥98% (by GC or NMR). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Density (at 20°C)	~0.94 g/mL
Refractive Index (n20D)	~1.425
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.