Description

1-Propanone, 2,3,3,3-Tetrafluoro-1-(4-Methylphenyl)- (9Ci) is a specialized fluorinated aromatic ketone, identified by CAS number 76435-42-2, valued for its unique molecular structure that combines a p-tolyl group with a tetrafluoropropanone moiety. This compound is a critical advanced intermediate in the synthesis of complex molecules, particularly in high-value sectors where the introduction of fluorine atoms is essential for modulating biological activity and material properties. It is primarily sought by pharmaceutical research and agrochemical development teams, as well as by material scientists working on specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases, where fluorination enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve pesticidal activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies (LCDs), where it contributes to improved dielectric anisotropy and thermal stability.
• Specialty Polymer Modifier: Incorporated into polymer chains to create materials with enhanced chemical resistance, lower surface energy, and improved optical properties for coatings and high-performance plastics.
• Organic Electronics: Investigated as a component in the synthesis of organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development and exploring new reactions in fluoroorganic chemistry.

Basic Information

Item	Details
Product Name	1-Propanone, 2,3,3,3-Tetrafluoro-1-(4-Methylphenyl)- (9Ci)
CAS No.	76435-42-2
Molecular Formula	C10H8F4O
Molecular Weight	220.16 g/mol
Synonyms	2,3,3,3-Tetrafluoro-1-(4-methylphenyl)propan-1-one; 4-Methyl-α,α,α-trifluoroacetophenone (partially related); p-Tolyl 2,3,3,3-tetrafluoro-1-oxopropyl ketone; 1-(4-Methylphenyl)-2,3,3,3-tetrafluoropropan-1-one; 4-Methylbenzoyltrifluoromethane (derivative); FTO (Fluorinated Tolyl Oxo compound); 76435-42-2 (CAS Registry)
EINECS	Contact for details

Quality Control

Our production of 1-Propanone, 2,3,3,3-Tetrafluoro-1-(4-Methylphenyl)- adheres to a rigorous quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity assessment, GC for residual solvent analysis, and NMR/IR for structural confirmation, to ensure it meets precise customer specifications. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific regulatory or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed when not in use to minimize exposure to moisture and air. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.