Description

(-)-1-[2,3-Dihydro-2-(1-Hydroxy-1-Methylethyl)Benzofuran-5-Yl]Ethanone is a high-purity chiral benzofuran derivative, serving as a critical synthetic intermediate and building block in advanced organic synthesis. Its defined stereochemistry and functional groups make it a valuable precursor for the development of complex molecules with specific biological activity. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Asymmetric Synthesis: Used as a starting material or intermediate in stereoselective reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Serves as a reference standard or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Potential use in the development of molecular probes for studying biological pathways and target engagement.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and heterocyclic chemistry.

Basic Information

Product Name	(-)-1-[2,3-Dihydro-2-(1-Hydroxy-1-Methylethyl)Benzofuran-5-Yl]Ethanone
CAS No.	76236-23-2
Molecular Formula	C₁₃H₁₆O₃
Molecular Weight	220.26 g/mol
Synonyms	1-(2,3-Dihydro-2-(1-hydroxy-1-methylethyl)-5-benzofuranyl)ethanone; (2R)-1-[2,3-Dihydro-2-(1-hydroxy-1-methylethyl)-5-benzofuranyl]ethanone; (-)-1-[2,3-Dihydro-2-(1-Hydroxy-1-Methylethyl)-5-Benzofuranyl]Ethanone; 5-Acetyl-2,3-dihydro-2-(1-hydroxy-1-methylethyl)benzofuran; (R)-5-Acetyl-2,3-dihydro-2-(2-hydroxypropan-2-yl)benzofuran; 76236-23-2; (R)-enantiomer of the benzofuran ketone derivative.
EINECS	Contact for details

Quality Control

Our (-)-1-[2,3-Dihydro-2-(1-Hydroxy-1-Methylethyl)Benzofuran-5-Yl]Ethanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including chiral purity and impurity profiles, to support your research and development needs. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and specific tests are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.