Description

2,2,5,5-Tetramethyl-2,5-Dihydro-1H-Pyrrolo-3-Acetic Acid is a high-purity pyrrole derivative characterized by its unique sterically hindered structure and carboxylic acid functionality. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis, enabling the development of complex molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides and fungicides, leveraging its sterically hindered pyrrole core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-rich heterocyclic structure.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Utilized in research laboratories for methodological studies and the exploration of new chemical reactions involving hindered acids.

Basic Information

Product Name	2,2,5,5-Tetramethyl-2,5-Dihydro-1H-Pyrrolo-3-Acetic Acid
CAS No.	76194-00-8
Molecular Formula	C12H19NO2
Molecular Weight	209.29 g/mol
Synonyms	3-Carboxymethyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole; 1H-Pyrrole-3-acetic acid, 2,5-dihydro-2,2,5,5-tetramethyl-; 2,2,5,5-Tetramethyl-3-pyrroline-3-acetic acid; 2,5-Dihydro-2,2,5,5-tetramethyl-1H-pyrrole-3-acetic acid; TMDP-3-AA; Tetramethyl-dihydro-pyrrole acetic acid
EINECS	Contact for details

Quality Control

Our 2,2,5,5-Tetramethyl-2,5-Dihydro-1H-Pyrrolo-3-Acetic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.