Description

1-Methylpyrazole-4-Boronic Acid Pinacol Ester is a high-purity boronic ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where it is used to develop active pharmaceutical ingredients (APIs), advanced crop protection agents, and functional organic materials.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of novel drug candidates, particularly in constructing heterocyclic cores prevalent in medicinal chemistry.
• Agrochemical Synthesis: Used to create advanced active ingredients for herbicides, fungicides, and insecticides through palladium-catalyzed cross-coupling.
• Material Science Research: Serves as a precursor for organic electronic materials, including OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for biochemical research.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis services catering to R&D and scale-up projects.

Basic Information

Product Name	1-Methylpyrazole-4-Boronic Acid Pinacol Ester
CAS No.	76144-44-0
Molecular Formula	C10H17BN2O2
Molecular Weight	208.07 g/mol
Synonyms	1-Methyl-1H-pyrazole-4-boronic acid pinacol ester; 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Methylpyrazole-4-boronic acid neopentyl glycol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrazole; 1-Methyl-4-boronic acid pinacol ester pyrazole; 76144-44-0; B-1-Methyl-1H-pyrazol-4-yl-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Methylpyrazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of research and development, as well as scale-up manufacturing for regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.