Description

Ethanone, 2,2,2-Trifluoro-1-[4-(Methylamino)Phenyl]- (9Ci) is a specialized trifluoromethyl ketone derivative, a key building block in advanced organic synthesis. Its molecular structure, featuring a trifluoroacetyl group linked to a methylamino-substituted aromatic ring, makes it a valuable precursor for creating complex molecules with tailored properties. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical sectors, where it is used to synthesize novel active ingredients. Its precise reactivity profile offers chemists a reliable tool for introducing fluorinated motifs, which are critical for modulating the bioavailability and metabolic stability of target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Research: Serves as a crucial building block for novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Precursor: Used in the synthesis of advanced organic materials, including liquid crystals, organic semiconductors, and polymers with specific optical or electronic properties.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create fluorinated analogs for structure-activity relationship (SAR) studies and as mechanistic probes in biochemical assays.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-[4-(Methylamino)Phenyl]- (9Ci)
CAS No.	75822-12-7
Molecular Formula	C9H8F3NO
Molecular Weight	203.16 g/mol
Synonyms	1-[4-(Methylamino)phenyl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-(methylamino)phenyl]ethanone; 4'-(Methylamino)-2,2,2-trifluoroacetophenone; N-Methyl-4-(trifluoroacetyl)aniline; 4-(Trifluoroacetyl)-N-methylaniline; α,α,α-Trifluoro-4'-(methylamino)acetophenone; TFMPA derivative
EINECS	Contact for details

Quality Control

Our production of Ethanone, 2,2,2-Trifluoro-1-[4-(Methylamino)Phenyl]- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot undergoes comprehensive analytical characterization using HPLC, GC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with REACH and other global regulatory frameworks, and can tailor specifications to meet specific project requirements or cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.