Description

3,5-Bis(Trifluoromethyl)Benzyl Chloride is a versatile and highly reactive organofluorine building block. Its value lies in the unique properties imparted by the two trifluoromethyl groups, which are critical for modifying the lipophilicity, metabolic stability, and electronic characteristics of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for synthesizing advanced active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Employed in the production of monomers for specialty polymers and liquid crystals, contributing to unique thermal and optical properties.
• Fluorinated Dye and Pigment Synthesis: Acts as a key intermediate for creating dyes and pigments with improved lightfastness and chemical resistance.
• Custom Synthesis and R&D: A valuable reagent for medicinal chemistry and discovery chemistry programs focused on structure-activity relationship (SAR) studies.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzyl Chloride
CAS No.	75462-59-8
Molecular Formula	C9H5ClF6
Molecular Weight	262.58 g/mol
Synonyms	α-Chloro-3,5-bis(trifluoromethyl)toluene; (3,5-Bis(trifluoromethyl)phenyl)methyl chloride; 1-(Chloromethyl)-3,5-bis(trifluoromethyl)benzene; 3,5-Bis(trifluoromethyl)benzylchloride; 3,5-Di(trifluoromethyl)benzyl chloride; α,α,α,α',α',α'-Hexafluoro-3,5-xylyl chloride; Benzene, 1-(chloromethyl)-3,5-bis(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its reactivity as an organic chloride and sensitivity to moisture, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain purity and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.