Description

(2S)-3,3A-Dihydro-3Aα-Methoxy-3α-Methyl-5-(2-Propenyl)-2α-(3,4,5-Trimethoxyphenyl)-6(2H)-Benzofuranone is a complex chiral benzofuranone derivative of significant interest in advanced organic synthesis. This compound serves as a critical synthetic intermediate for constructing pharmacologically active molecules, particularly those with complex stereocenters. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-cancer research.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce complex molecular architectures with defined chirality.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value, low-volume specialty chemicals for research and development.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(2S)-3,3A-Dihydro-3Aα-Methoxy-3α-Methyl-5-(2-Propenyl)-2α-(3,4,5-Trimethoxyphenyl)-6(2H)-Benzofuranone
CAS No.	75363-17-6
Molecular Formula	C24H28O6
Molecular Weight	412.48 g/mol
Synonyms	(2S)-3,3a-Dihydro-3a-methoxy-3a-methyl-5-(prop-2-en-1-yl)-2a-(3,4,5-trimethoxyphenyl)-6H-benzofuran-6-one; (2S)-3,3a-Dihydro-3a-methoxy-3a-methyl-5-(2-propenyl)-2a-(3,4,5-trimethoxyphenyl)-6(2H)-benzofuranone; 75363-17-6; (2S)-3,3a-Dihydro-3a-methoxy-3a-methyl-5-allyl-2a-(3,4,5-trimethoxyphenyl)-6(2H)-benzofuranone; Chiral Benzofuranone Derivative; 3a-Methoxy-3a-methyl-5-allyl-2a-(3,4,5-trimethoxyphenyl)-3,3a-dihydro-6(2H)-benzofuranone (S-isomer)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. We employ advanced analytical techniques including HPLC, GC, and NMR to verify identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing lot-specific results are available upon request. Our quality management system supports the needs of customers operating under GMP and other regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.