Description

S-(Trifluoroacetyl)-4-Mercaptotoluene is a specialized organosulfur and organofluorine building block characterized by its reactive thiol group protected by a trifluoroacetyl moiety. This compound matters for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research where the introduction of fluorine atoms and sulfur-containing functional groups is critical. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing thioether or fluorinated motifs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides, herbicides, and fungicides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of advanced polymers and functional materials with specific surface properties or reactivity.
• Chemical Biology Probes: Useful for synthesizing probes and linkers in bioconjugation chemistry and proteomics research.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	S-(Trifluoroacetyl)-4-Mercaptotoluene
CAS No.	75072-07-0
Molecular Formula	C9H7F3OS
Molecular Weight	220.21 g/mol
Synonyms	4-Methyl-α-(trifluoroacetylthio)toluene; p-Tolyl Trifluoroacetyl Sulfide; 4-(Trifluoroacetylthio)toluene; 1-Methyl-4-[(trifluoroacetyl)thio]benzene; S-Trifluoroacetyl-4-thiocresol; α,α,α-Trifluoro-4-methylbenzenethiol acetate; 4-Methylbenzenethiol S-trifluoroacetate
EINECS	Contact for details

Quality Control

Our S-(Trifluoroacetyl)-4-Mercaptotoluene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.