Description

3-Chloro-1H-Indole-2-Carbonitrile is a versatile and high-value indole derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated and nitrile-substituted structure makes it an indispensable intermediate for constructing complex heterocyclic frameworks. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and plant growth regulators, leveraging its heterocyclic core for biological activity.
• Material Science Research: Acts as a monomer or functional unit in the development of organic semiconductors, dyes, and photoactive materials.
• Chemical Biology: Employed as a molecular probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Academic & Contract Research: Essential for methodological development and novel reaction pathway exploration in university and CRO laboratory settings.

Basic Information

Product Name	3-Chloro-1H-Indole-2-Carbonitrile
CAS No.	74960-46-6
Molecular Formula	C9H5ClN2
Molecular Weight	176.60 g/mol
Synonyms	3-Chloroindole-2-carbonitrile; 2-Cyano-3-chloroindole; 3-Chloro-1H-indole-2-carbonitrile; 1H-Indole-2-carbonitrile, 3-chloro-; 3-Chloroindole-2-CN
EINECS	Contact for details

Quality Control

Our 3-Chloro-1H-Indole-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.