Description

4-(Trifluoromethyl)-Alpha,Alpha,α-Trifluoroacetophenone is a high-value, fluorinated aromatic ketone building block, distinguished by its unique trifluoromethyl and trifluoroacetyl functional groups. This compound is prized for its ability to impart significant lipophilicity, metabolic stability, and electron-withdrawing properties to advanced molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and other small molecule therapeutics where fluorine substitution is beneficial.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display technologies and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter surface properties, increase chemical resistance, and adjust refractive index for optical applications.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic additions, and as a precursor for heterocyclic compounds in advanced organic chemistry R&D.

Basic Information

Product Name	4-(Trifluoromethyl)-Alpha,Alpha,α-Trifluoroacetophenone
CAS No.	74853-66-0
Molecular Formula	C9H4F6O
Molecular Weight	242.12 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]-2,2,2-trifluoroethanone; 4-(Trifluoromethyl)phenyl trifluoromethyl ketone; p-(Trifluoromethyl)trifluoroacetophenone; α,α,α,4-Tetrafluoroacetophenone; 2,2,2-Trifluoro-1-[4-(trifluoromethyl)phenyl]ethanone; 4-Trifluoromethyl-α,α,α-trifluoroacetophenone; TFAP; Contact for additional names.
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-Alpha,Alpha,α-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.