Description

4,6-Bis(1,1-Dimethylethyl)-2-Ethyl-4-Methyl-4H-1,3,2-Dioxaborin is a specialized organoboron compound, specifically a cyclic boronic ester, valued for its role as a key synthetic intermediate and protecting group in advanced organic synthesis. Its unique sterically hindered structure provides enhanced stability, making it a crucial reagent for the controlled formation of carbon-boron bonds, which are pivotal in cross-coupling reactions. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors developing novel active ingredients and functional polymers. CAS No. 74646-13-2.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug candidates, particularly in Suzuki-Miyaura cross-coupling reactions to form biaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific boron-containing motifs.
• Materials Science & OLED Development: Acts as a precursor for creating organic light-emitting diode (OLED) materials and other advanced electronic compounds where boron doping is beneficial.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and boron-based monomers for high-performance materials.
• Academic & Industrial R&D: A valuable reagent for methodological development in organometallic chemistry and catalysis research.
• Boronic Acid & Ester Protection: Functions as a protected form of a boronic acid, offering improved handling and stability for multi-step synthetic sequences.

Basic Information

Product Name	4,6-Bis(1,1-Dimethylethyl)-2-Ethyl-4-Methyl-4H-1,3,2-Dioxaborin
CAS No.	74646-13-2
Molecular Formula	C13H25BO2
Molecular Weight	224.15 g/mol
Synonyms	2-Ethyl-4-methyl-4,6-di-tert-butyl-1,3,2-dioxaborinane; 4,6-Di-tert-butyl-2-ethyl-4-methyl-1,3,2-dioxaborinane; Cyclic Ethylmethyl-tert-butylboronate; 4H-1,3,2-Dioxaborin, 4,6-bis(1,1-dimethylethyl)-2-ethyl-4-methyl-; tert-Butyl Ethyl Methyl Boronic Ester (cyclic); B-[(1,1-Dimethylethyl)oxy]-B-ethyl-B-methylborinic anhydride with (1,1-dimethylethyl)boronic acid (cyclic form)
EINECS	Contact for details

Quality Control

Our 4,6-Bis(1,1-Dimethylethyl)-2-Ethyl-4-Methyl-4H-1,3,2-Dioxaborin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.