Description

2-Ethyl-1,3,2-Dioxaborolan-4-One CAS NO 74646-12-1 is a specialized organoboron compound, specifically a cyclic boronic ester, valued for its role as a versatile synthetic intermediate. Its structure makes it a crucial reagent in modern organic synthesis, particularly for cross-coupling reactions and the protection of diols. This chemical is essential for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and advanced materials sectors seeking to build complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring boron-containing motifs for Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides, where its boronate ester functionality enables efficient carbon-carbon bond formation.
• Polymer & Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, resins, and boron-based advanced materials.
• Organic Synthesis Reagent: Functions as a protecting group for cis-1,2-diols and as a transesterification agent in complex multi-step synthetic routes.
• Ligand & Catalyst Preparation: Utilized in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and boron chemistry.

Basic Information

Product Name	2-Ethyl-1,3,2-Dioxaborolan-4-One
CAS No.	74646-12-1
Molecular Formula	C5H9BO3
Molecular Weight	127.94 g/mol
Synonyms	2-Ethyl-1,3,2-dioxaborolane-4-one; 2-Ethyl-1,3,2-dioxaborolan-4-one; Ethylboronic acid cyclic ester with glycolic acid; Glycolic acid ethylboronate; 4-Oxo-2-ethyl-1,3,2-dioxaborolane; 2-Ethyl-4H-1,3,2-benzodioxaborin-4-one (related structure, verify); Ethyl glycolato boronate
EINECS	Contact for details

Quality Control

Our 2-Ethyl-1,3,2-Dioxaborolan-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.