Description

1H-Indole-3-Acetic Acid, 5-Chloro-2-Methyl-1-(Trimethylsilyl)-, Trimethylsilyl Ester is a specialized organosilicon derivative of a halogenated indole acetic acid, serving as a key protected intermediate in advanced organic synthesis. This compound is valued for its role in facilitating complex chemical transformations where the sensitive carboxylic acid and indole functionalities require temporary protection. It is primarily sought by research and development laboratories and fine chemical manufacturers engaged in the synthesis of novel agrochemicals, pharmaceuticals, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel drug candidates, particularly those targeting neurological or hormonal pathways.
• Agrochemical Research: Used in the development of new plant growth regulators or herbicides, leveraging the structural motif of indole acetic acid.
• Organic Synthesis Reagent: Acts as a protected synthon in complex organic reactions, where the trimethylsilyl (TMS) groups provide stability under specific reaction conditions.
• Biochemical Probe Development: Employed in research to create labeled or modified analogs for studying plant hormone (auxin) signaling and metabolism.
• Material Science Precursor: Potential use in the synthesis of specialized organic semiconductors or advanced polymeric materials with unique electronic properties.

Basic Information

Product Name	1H-Indole-3-Acetic Acid, 5-Chloro-2-Methyl-1-(Trimethylsilyl)-, Trimethylsilyl Ester
CAS No.	74367-57-0
Molecular Formula	C₁₇H₂₄ClNO₂Si₂
Molecular Weight	373.01 g/mol
Synonyms	5-Chloro-2-methyl-1-(trimethylsilyl)-1H-indol-3-yl acetate trimethylsilyl ester; 5-Chloro-2-methyl-1-trimethylsilylindole-3-acetic acid TMS ester; 1-(Trimethylsilyl)-5-chloro-2-methylindole-3-acetic acid trimethylsilyl ester; 74367-57-0; TMS ester of 5-Chloro-2-methyl-1-(trimethylsilyl)indole-3-acetic acid; Protected 5-Chloro-2-methylindole-3-acetic acid; Silicon-protected indole acetic acid derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.