Description

[[Estra-1,3,5(10)-Triene-3,16β-Diyl]Bis(Oxy)]Bis(Trimethylsilane) is a high-purity, protected steroid derivative used as a critical synthetic intermediate in advanced pharmaceutical research and development. Its primary value lies in enabling the controlled synthesis of complex estrane-based molecules, offering researchers a versatile building block for creating novel therapeutic agents. This compound is essential for R&D chemists and process development scientists working in steroid chemistry, oncology, endocrinology, and the development of hormone-based pharmaceuticals.

Application

• Pharmaceutical Intermediate: A key protected precursor in the multi-step synthesis of novel steroidal drugs and active pharmaceutical ingredients (APIs).
• Steroid Chemistry Research: Enables the exploration of new estrane derivatives with potential therapeutic applications in hormone replacement therapy and cancer treatment.
• Process Development: Serves as a standardized starting material for scaling up and optimizing synthetic routes in pilot plant and manufacturing settings.
• Academic & Industrial R&D: Used in laboratories for investigating structure-activity relationships (SAR) and developing new synthetic methodologies in organic chemistry.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	[[Estra-1,3,5(10)-Triene-3,16β-Diyl]Bis(Oxy)]Bis(Trimethylsilane)
CAS No.	74299-36-8
Molecular Formula	C24H40O2Si2
Molecular Weight	416.75 g/mol
Synonyms	3,16β-Bis(trimethylsilyloxy)estra-1,3,5(10)-triene; Estra-1,3,5(10)-triene-3,16β-diol bis(trimethylsilyl) ether; 3,16β-Bis-O-(trimethylsilyl)estra-1,3,5(10)-triene; 16β-Hydroxyestrone 3,16-bis(trimethylsilyl) ether; Estrone 3,16β-bis(trimethylsilyl) ether; 3,16β-Di-O-trimethylsilyl-estra-1,3,5(10)-triene; Protected Estrone Derivative; Silylated Estradiol Precursor
EINECS	Contact for details

Quality Control

Our [[Estra-1,3,5(10)-Triene-3,16β-Diyl]Bis(Oxy)]Bis(Trimethylsilane) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.